abstract：INTRODUCTION:Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulatio...

journal_title：Parkinsonism & related disorders

authors： Trung J,Hanganu A,Jobert S,Degroot C,Mejia-Constain B,Kibreab M,Bruneau MA,Lafontaine AL,Strafella A,Monchi O

更新日期：2019-09-01 00:00:00

abstract：:Invasive human brain recordings have shown that acute therapeutic deep brain stimulation (DBS) reduces cortical synchronization, measured by coupling of beta phase to gamma amplitude. Here we show by noninvasive scalp electroencephalography that withdrawal of chronic DBS elevates phase-amplitude coupling, in proportio...

journal_title：Parkinsonism & related disorders

authors： Rajagopalan SS,Miller AM,de Hemptinne C,San Luciano M,Ostrem JL,Starr PA

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Spinocerebellar ataxia 48 has recently been described as an adult onset ataxia associated with a cerebellar cognitive affective syndrome, caused by a heterozygous mutation in the STUB1 gene. METHODS:We characterized the clinical and neuroimaging phenotype of eight patients from two autosomal dominant atax...

journal_title：Parkinsonism & related disorders

authors： De Michele G,Lieto M,Galatolo D,Salvatore E,Cocozza S,Barghigiani M,Tessa A,Baldacci J,Pappatà S,Filla A,De Michele G,Santorelli FM

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

journal_title：Parkinsonism & related disorders

authors： Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Parkinson's disease patients may be at increased risk of delirium and developing adverse outcomes, such as cognitive decline and increased mortality. Delirium is an acute state of confusion that has overlapping symptoms with Parkinson's dementia, making it difficult to identify. This study aimed to determine...

journal_title：Parkinsonism & related disorders

authors： Lawson RA,McDonald C,Burn DJ

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Although the hallmark feature of essential tremor (ET) is tremor, there is growing appreciation that cognitive impairment also occurs, including increased prevalence of mild cognitive impairment (MCI) and increased prevalence and incidence of dementia. With emerging knowledge of ET-cognitive impairment, co...

journal_title：Parkinsonism & related disorders

authors： Louis ED,Joyce JL,Cosentino S

更新日期：2019-06-01 00:00:00

abstract：:Myoclonus is a sudden and brief involuntary muscle contraction presenting with jerk-like movements that can occasionally involve the trunk muscles or the diaphragm as in the case of spinal myoclonus1. We here present an unusual case with unilateral diaphragmatic myoclonus owing to electrode dislocation of an implantab...

journal_title：Parkinsonism & related disorders

authors： Bedarf JR,Nitsch L,Malotki R,Andrié R,Reimann J

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Several evidences demonstrated the role of white matter (WM) lesions in the pathogenesis of Vascular Parkinsonism (VP), a clinical entity characterized by parkinsonism, postural instability, marked gait difficulty and poor response to levodopa. However, the involvement of normal appearing white matter (NAWM) ...

journal_title：Parkinsonism & related disorders

authors： Salsone M,Caligiuri ME,Vescio V,Arabia G,Cherubini A,Nicoletti G,Morelli M,Quattrone A,Vescio B,Nisticò R,Novellino F,Cascini GL,Sabatini U,Montilla M,Rektor I,Quattrone A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compar...

journal_title：Parkinsonism & related disorders

authors： Vivacqua G,Suppa A,Mancinelli R,Belvisi D,Fabbrini A,Costanzo M,Formica A,Onori P,Fabbrini G,Berardelli A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Executive dysfunction is a common and early cognitive symptom in Parkinson's disease (PD) with a detrimental effect on quality of life of patients and their care givers. Thus, a number of neuroimaging studies investigated the underlying neural correlates of such an impairment. Results of individual studies...

journal_title：Parkinsonism & related disorders

authors： Giehl K,Tahmasian M,Eickhoff SB,van Eimeren T

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To confirm that there is a diagnostic delay in Parkin-related Parkinson Disease and to explore possible factors causing such a delay. METHODS:We retrospectively analyzed our patients with mutations in the parkin RBR E3 ubiquitin protein ligase gene (PRKN). We collected a total of 34 patients and focused on 1...

journal_title：Parkinsonism & related disorders

authors： Ruiz-Lopez M,Freitas ME,Oliveira LM,Munhoz RP,Fox SH,Rohani M,Rogaeva E,Lang AE,Fasano A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

journal_title：Parkinsonism & related disorders

authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:We sought to assess the effect of subthalamic deep brain stimulation (STN DBS) on Parkinson's disease (PD)-associated postural abnormalities. METHODS:A computerized analysis of posture was used to quantify the thoracolumbar, thoracic, and cervical-occipital ventral angles, as well as the thoracolumbar and...

journal_title：Parkinsonism & related disorders

authors： Roediger J,Artusi CA,Romagnolo A,Boyne P,Zibetti M,Lopiano L,Espay AJ,Fasano A,Merola A

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures...

journal_title：Parkinsonism & related disorders

authors： Galperin I,Hillel I,Del Din S,Bekkers EMJ,Nieuwboer A,Abbruzzese G,Avanzino L,Nieuwhof F,Bloem BR,Rochester L,Della Croce U,Cereatti A,Giladi N,Mirelman A,Hausdorff JM

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:PLA2G6-associated neurodegeneration (PLAN) comprises a continuum of three phenotypes with overlapping clinical and radiologic features. METHODS:Observational clinical study in a cohort of infantile and childhood onset PLAN patients and genetic analysis of the PLA2G6 gene. We analysed chronological evoluti...

journal_title：Parkinsonism & related disorders

authors： Darling A,Aguilera-Albesa S,Tello CA,Serrano M,Tomás M,Camino-León R,Fernández-Ramos J,Jiménez-Escrig A,Poó P,O'Callaghan M,Ortez C,Nascimento A,Fernández Mesaque RC,Madruga M,Arrabal L,Roldan S,Gómez-Martín H,Garrido C

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:X-linked dystonia-parkinsonism (XDP) is characterized by the unique transition of dystonia to parkinsonism and striatal degeneration. Slowing of saccades on clinical examination has been taken as suggestive of a progressive supranuclear palsy (PSP) phenotype. OBJECTIVES:To elucidate whether eye movement abn...

journal_title：Parkinsonism & related disorders

authors： Sprenger A,Hanssen H,Hagedorn I,Prasuhn J,Rosales RL,Jamora RDG,Diesta CC,Domingo A,Klein C,Brüggemann N,Helmchen C

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:There are few studies reporting characteristics of patients with cerebellar ataxias in the Brazilian population. The aim of this study was to provide a detailed neurological description of patients with hereditary ataxia followed by a neurology outpatient service in Brazil. METHODS:Neurological and clinical...

journal_title：Parkinsonism & related disorders

authors： Rangel DM,Nóbrega PR,Saraiva-Pereira ML,Jardim LB,Braga-Neto P

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Cognitive dysfunction is common in progressive supranuclear palsy (PSP) but its effect on medical decision-making has not been well studied. To address this gap in the research literature, we compared the medical decision-making capacity of patients with PSP to groups of patients with other neurodegenerati...

journal_title：Parkinsonism & related disorders

authors： Gerstenecker A,Grimsley L,Otruba B,Cowden L,Marson DC,Gerstenecker KT,Martin RC,Roberson ED

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:There is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study. METHODS:We conducted a d...

journal_title：Parkinsonism & related disorders

authors： Corvol JC,Durif F,Meissner WG,Azulay JP,Haddad R,Guimarães-Costa R,Mariani LL,Cormier-Dequaire F,Thalamas C,Galitzky M,Boraud T,Debilly B,Eusebio A,Houot M,Dellapina E,Chaigneau V,Salis A,Lacomblez L,Benel L,Rascol

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Huntington's Disease (HD) cognitive dysfunction occurs before unequivocal motor signs become apparent. The predominant early cognitive abnormal domains may include deficits in psychomotor speed, negative emotion recognition and executive functioning. Our study is aimed to investigate the executive control ...

journal_title：Parkinsonism & related disorders

authors： Migliore S,D'Aurizio G,Curcio G,Squitieri F

更新日期：2019-03-01 00:00:00

abstract：:Tardive dyskinesia (TD) is a common, iatrogenic movement disorder affecting many individuals treated with dopamine-receptor blocking agents (DRBAs). Studying treatment of TD can be complex, as the symptoms can be affected by changes in either dosage or type of DRBA, as well as by the variable natural course of the dis...

journal_title：Parkinsonism & related disorders

authors： Margolius A,Fernandez HH

更新日期：2019-02-01 00:00:00

abstract：:To establish a clinical diagnosis of a parkinsonian disorder, physicians rely on their ability to identify relevant red flags, in addition to cardinal features, to support or refute their working diagnosis in an individual patient. The term 'red flag', was originally coined in 1989 to define the presence of non-cardin...

journal_title：Parkinsonism & related disorders

authors： Bhidayasiri R,Sringean J,Reich SG,Colosimo C

更新日期：2019-02-01 00:00:00

abstract：:Today, the basal ganglia (BG) network can be viewed as a three-layer neural network in which the striatum and the subthalamic nucleus (STN) are the two BG input structures and together innervate BG downstream structures using GABA and glutamate, respectively. The striatum is larger than the STN and is the main site of...

journal_title：Parkinsonism & related disorders

authors： Deffains M,Bergman H

更新日期：2019-02-01 00:00:00

abstract：:Significant advances in the symptomatic treatment of Parkinson disease (PD) have occurred since the discovery of levodopa (LD). Perhaps as a testament to its unparalleled efficacy, novel formulations aiming to optimize LD delivery to obtain better bioavailability, longer duration of effect and less plasma level fluctu...

journal_title：Parkinsonism & related disorders

authors： Hengartner D,Fernandez HH

更新日期：2019-02-01 00:00:00

abstract：:Diagnostic biomarkers are measures that detect or confirm the presence of a disease or identify individuals with a subtype of the disease. For Parkinson's disease, unlike other neurodegenerative diseases such as Alzheimer's disease and Creutzfeldt-Jakob disease, diagnostic biomarkers remain elusive as none are yet ava...

journal_title：Parkinsonism & related disorders

authors： Kalia LV

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Parkinson's disease is characterized by pathological α-synuclein accumulation and cell death, which has been hypothesized to originate in peripheral nerve terminals and subsequently spread via autonomic nerves. Supporting this, most Parkinson's disease patients experience autonomic non-motor symptoms such as...

journal_title：Parkinsonism & related disorders

authors： Knudsen K,Fedorova TD,Hansen AK,Sommerauer M,Haase AM,Svendsen KB,Otto M,Østergaard K,Krogh K,Borghammer P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently been shown to be an effective treatment for Meige syndrome but efficacy of symptomatic improvement and its relationship to factors in DBS remains to be explored. OBJECTIVES:This study explored the relationship of electrode contact location ...

journal_title：Parkinsonism & related disorders

authors： Yao C,Horn A,Li N,Lu Y,Fu Z,Wang N,Aziz TZ,Wang L,Zhang S

更新日期：2019-01-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is an inborn error of cholesterol and bile acid metabolism, leading to neuropsychiatric and systemic manifestations. Movement disorders have rarely been reported in CTX, while a detailed appreciation of the full phenotypic spectrum is required in order to prevent underdiagnosis of ...

journal_title：Parkinsonism & related disorders

authors： Stelten BML,van de Warrenburg BPC,Wevers RA,Verrips A

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:We aimed to evaluate whether neuromelanin-sensitive MRI (NM-MRI) features in the substantia nigra pars compacta (SNc) were of diagnostic value to differentiate untreated essential tremor (ET) from de novo tremor-dominant Parkinson's disease (PDT). METHODS:Eighteen untreated ET patients, 21 de novo PDT pat...

journal_title：Parkinsonism & related disorders

authors： Wang J,Huang Z,Li Y,Ye F,Wang C,Zhang Y,Cheng X,Fei G,Liu K,Zeng M,Zhong C,Jin L

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Many patients with Parkinson's disease (PD) suffer from sialorrhea. Sialorrhea is often treated with anticholinergics and botulinum toxin, but some adverse effects have limited the use of these treatments. Dihydroergotoxine mesylate is an α-adrenergic blocking agents as well as some affinities to the dopamin...

journal_title：Parkinsonism & related disorders

authors： Cheng YQ,Ge NN,Zhu HH,Sha ZT,Jiang T,Zhang YD,Tian YY

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The deep brain stimulation (DBS) withdrawal syndrome (DBS-WDS) is a rare, life-threatening complication in Parkinson's disease (PD) patients with long disease duration and stimulation when stimulation is terminated for extended periods mostly due to infection of the DBS-hardware. METHODS, RESULTS:In five ...

journal_title：Parkinsonism & related disorders

authors： Reuter S,Deuschl G,Berg D,Helmers A,Falk D,Witt K

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention...

journal_title：Parkinsonism & related disorders

authors： Tan AH,Hew YC,Lim SY,Ramli NM,Kamaruzzaman SB,Tan MP,Grossmann M,Ang BH,Tan JY,Manap MAAA,Tay TK,Tan SL,New RP,Fadzli F,Yee EJ,Moy FM,Mahadeva S,Lang AE

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:The DUALITY trial recently showed that both integrated and consecutive dual-task training improve dual-task gait velocity, without increasing fall risks in patients with Parkinson's disease (PD). Gait velocity was the primary outcome; not reported, however, were important gait measures related to the risk ...

journal_title：Parkinsonism & related disorders

authors： Geroin C,Nonnekes J,de Vries NM,Strouwen C,Smania N,Tinazzi M,Nieuwboer A,Bloem BR

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:While metals have been implicated in the pathophysiology of Parkinson's disease (PD), the clinical evidence is scarce. Further, the contribution of metals for the risk or clinical presentation of PD remains to be explored. METHODS:To investigate the associations between the level of metals in blood serum ...

journal_title：Parkinsonism & related disorders

authors： Kim MJ,Oh SB,Kim J,Kim K,Ryu HS,Kim MS,Ayton S,Bush AI,Lee JY,Chung SJ

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:The age of diagnosis of Huntington's disease (HD) varies among individuals with the same HTT CAG-repeat expansion size. We investigated whether early-life events, like perinatal insults or neurodevelopmental disorders, influence the diagnosis age. METHODS:We used data from 13,856 participants from REGISTR...

journal_title：Parkinsonism & related disorders

authors： Barkhuizen M,Rodrigues FB,Anderson DG,Winkens B,REGISTRY Investigators of the European Huntington's Disease Network.,Wild EJ,Kramer BW,Gavilanes AWD

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Patients with Parkinson's disease (PD) frequently lose weight, even in the early stages of the disease. Our objective was to clarify the association between low body mass index (BMI) and life prognosis in PD. METHODS:We conducted a retrospective cohort study of 651 PD patients (380 females), with a primar...

journal_title：Parkinsonism & related disorders

authors： Park K,Oeda T,Kohsaka M,Tomita S,Umemura A,Sawada H

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:DBS is a well-established therapy for patients with PD and is an emerging therapy for other neuropsychiatric disorders. Despite the rise in DBS usage, relatively little is known about the tissue and cellular responses to DBS. PURPOSE:To examine post-mortem effects of DBS leads by objectively quantifying gli...

journal_title：Parkinsonism & related disorders

authors： Vedam-Mai V,Rodgers C,Gureck A,Vincent M,Ippolito G,Elkouzi A,Yachnis AT,Foote KD,Okun MS

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Non-motor symptoms in Parkinson's disease (PD), such as cognitive, emotional, autonomic and somatosensory alterations, are not ubiquitous but vary between the tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtypes of the syndrome. Non-motor phenomena (e.g., anxiety, depression and apat...

journal_title：Parkinsonism & related disorders

authors： Santangelo G,Vitale C,Baiano C,D'Iorio A,Longo K,Barone P,Amboni M,Conson M

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Camptocormia is defined as an involuntary, marked flexion of the thoracolumbar spine appearing during standing or walking and resolving in the supine position or when leaning against a wall. However, there is no established agreement on the minimum degree of forward flexion needed to diagnose camptocormia....

journal_title：Parkinsonism & related disorders

authors： Fasano A,Geroin C,Berardelli A,Bloem BR,Espay AJ,Hallett M,Lang AE,Tinazzi M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Somatosensory abnormalities contribute to the pathophysiology of Parkinson's disease (PD). The goal of this study was to identify abnormalities in the tactile-evoked activation of the somatosensory and motor cortices in PD, and in a sensorimotor circuit that traverses both of these cortical loci. The second ...

journal_title：Parkinsonism & related disorders

authors： Nelson AJ,Hoque T,Gunraj C,Chen R

更新日期：2018-08-01 00:00:00